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Impact of Antidepressant Use on Gastric Bypass Surgery Patients’ Weight Loss and Health-Related Quality-of-Life Outcomes

Received October 29, 2006; revised March 28, 2007; accepted April 5, 2007. From Wilford Hall Medical Center and University of Texas Health Science Center at San Antonio, and the University of Missouri–Kansas City School of Medicine. Send correspondence and reprint requests to Dr. Robert J. Love, Psychiatry Resident, Department of Psychiatry, Wilford Hall Medical Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78249. e-mail: Robert.Love2{at}dover.af.mil
© 2008 The Academy of Psychosomatic Medicine

BACKGROUND: Psychological factors may be predictive of post-surgical adjustment and successful outcomes in obesity-surgery populations. OBJECTIVE: The authors compared post–gastric bypass surgery (GBS) outcomes of patients being given active psychotropic treatment for depression, with those of patients without treatment or identifiable need for treatment at enrollment. METHOD: Outcome measures included weight and repeated administration of the Medical Outcome Survey Short Form–36 (SF–36). RESULTS: There was no impact of antidepressant treatment on GBS patients’ weight loss or SF–36 outcomes. CONCLUSION: Therefore, patients with actively treated depression should be expected to have GBS outcomes equivalent to those of patients without identifiable psychiatric illness or treatment.

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