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Cancer Fatigue: A Neurobiological Review for Psychiatrists

Received November 6, 2006; revised April 13, 2007; accepted April 24, 2007. From the Dept. of Psychiatry, Univ. of Washington, Seattle, WA. Send correspondence and reprint requests to Mitchell Levy, M.D., Dept. of Psychiatry, Univ. of Washington, 4225 Roosevelt Way, Suite 306, Seattle, WA 98105. e-mail: mrlevy{at}u.washington.edu
© 2008 The Academy of Psychosomatic Medicine

BACKGROUND: Fatigue, both during and subsequent to treatment, is a ubiquitous and debilitating phenomenon for patients undergoing treatment for cancer of all types. OBJECTIVE: This review will focus on understanding the complex neurobiological mechanisms underlying the phenomenon of cancer-related fatigue (CRF) and their relevance for various treatment routes. METHOD: The review will describe the prevalence of CRF, differential diagnosis, consideration of neurobiological mechanisms, and routes for intervention. DISCUSSION: The review will provide suggestions for future study and research, and a future article will describe behavioral and educational strategies psychiatrists may use in alleviating cancer fatigue.

Key Words: Cancer • Fatigue • Cytokines • Interferon • Neuropsychiatry

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