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Severe Acute Hyperammonemia After Brief Exposure to Valproate

Received January 16, 2007; revised February 1, 2007; accepted February 20, 2007. From the Dept. of Psychiatry and Behavioral Sciences, Univ. of California, Davis Medical Center, Sacramento CA. Send correspondence and reprint requests to James A. Bourgeois, O.D., M.D., Dept. of Psychiatry and Behavioral Sciences, Univ. of California, Davis Medical Center, 2230 Stockton Blvd., Sacramento CA 95817. e-mail: james.bourgeois{at}ucdmc.ucdavis.edu
© 2008 The Academy of Psychosomatic Medicine

The authors describe a case of acute hyperammonemia after the addition of valproate to the medication regimen of a patient on multiple psychotropic medications. The patient presented with acute mental-status changes consistent with delirium. With prompt intervention and supportive care, her delirium quickly cleared.

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