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Depression and IL-6 Blood Plasma Concentrations in Advanced Cancer Patients

Received June 22, 2006; revised September 28, 2006; accepted October 3, 2006. From Columbia University, NY State Psychiatric Institute; Fordham University; Memorial Sloan-Kettering Cancer Center. Send correspondence and reprint requests to Colleen Jacobson, Ph.D., Dept. of Child and Adolescent Psychiatry, Columbia University/NYSPI, 1051 Riverside Dr., New York, NY 10032. e-mail: jacobsoc{at}childpsych.columbia.edu
© 2008 The Academy of Psychosomatic Medicine

The authors explored the relationship between depression and interleukin-6 (IL-6) blood plasma concentrations among advanced-stage cancer patients. Seventy-three patients with advanced cancer were rated on depression with the Hamilton Rating Scale for Depression and gave blood to be assayed for blood plasma concentration of IL-6. Initial results found no correlation between depression and IL-6. Subsequent analyses found that among those whose blood was drawn within 48 hours of interview completion, depression and IL-6 were highly correlated. Future studies focusing on the relationship between immune functioning and depression must be particularly vigilant regarding methodological issues.

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