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Quetiapine-Induced Leucopenia and Thrombocytopenia

Received December 15, 2006; revised December 21, 2006; accepted January 7, 2007. From the Krishna Nursing Home, Tamil Nadu, India. Send correspondence and reprint requests to Dr. Shankar, 6AB, Swaranambika Lay Out, Coimbatore 641009, Tamil Nadu, India. e-mail: drravishankarbalu{at}gmail.com
© 2007 The Academy of Psychosomatic Medicine

Antipsychotic drugs can cause neutropenia, which can progress to life-threatening agranulocytosis if drug therapy is not interrupted. The newer atypical antipsychotics are reputedly without adverse hematological effects. Quetiapine is a recently introduced atypical antipsychotic. It is a dibenzothiazepine derivative and shows similarities with clozapine in that it is characterized by high 5-HT₂-relative-to-DA₂ receptor affinity. Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.

This article has been cited by other articles:

				A. Rahman, L. M Mican, C. Fischer, and A. H Campbell Evaluating the Incidence of Leukopenia and Neutropenia with Valproate, Quetiapine, or the Combination in Children and Adolescents Ann. Pharmacother., May 1, 2009; 43(5): 822 - 830. [Abstract] [Full Text] [PDF]

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