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Antiemetics, Akathisia, and Pregnancy

Received October 9, 2006; revised October 26, 2006; accepted November 1, 2006. From the Dept. of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI. Send correspondence and reprint requests to Mark T. Wright, M.D., Dept. of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226. e-mail: mwright{at}mcw.edu
© 2007 The Academy of Psychosomatic Medicine

Gastrointestinal disorders are common in pregnant women. These disorders are often treated with antiemetic medications that block central dopaminergic neurotransmission. Dopamine antagonists can cause akathisia. Hormonal changes and other factors may place pregnant women at increased risk for the development of severe antiemetic-induced akathisia. The mental symptoms that can accompany akathisia can be misinterpreted as primary mental illness. The author reports on the case of a pregnant woman who attempted to injure herself after developing severe antiemetic-induced akathisia.

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