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Are Anti-Nuclear Antibodies Common in Affective Disorders? A Review of the Past 35 Years

Received August 26, 2006; revised October 27, 2006; accepted November 1, 2006. From The Johns Hopkins Hospital, Baltimore, MD. Address correspondence and reprint requests to Brian Appleby, M.D., The Johns Hopkins Hospital, Meyer 131, 600 North Wolfe St., Baltimore, MD 21287. e-mail: bappleb1{at}jhmi.edu
© 2007 The Academy of Psychosomatic Medicine

There has been debate in the literature about whether or not positive anti-nuclear antibody (ANA) titers are associated with affective disorders. Using specific search criteria, the author conducted a search of PubMed over the past 35 years. Four studies showed a positive correlation, whereas eight did not. Some of the positive studies have confounding factors. Given that the positive studies have confounding factors and that there are more negative studies than positive ones, it is logical to assume that there is no association between ANA titer and affective disorders until a properly controlled study is conducted.

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