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Psychosomatics 47:533-536, December 2006
doi: 10.1176/appi.psy.47.6.533
© 2006 Academy of Psychosomatic Medicine
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Case Report

Cardioversion of Persistent Atrial Arrhythmia After Treatment With Venlafaxine in Successful Management of Major Depression and Posttraumatic Stress Disorder

Susan J. Finch, M.D., C.M., FRCPC, and Louis T. van Zyl, M.B.Ch.B., M.Med.Psych., FRCPC

Received September 13, 2005; accepted November 10, 2005. From the Dept. of Psychiatry, Queen’s University, Kingston, Ontario, Canada. Address correspondence and reprint requests to Dr. Finch, Hotel Dieu Hospital, 166 Brock St., Kingston, Ontario, Canada K7L 5G2. e-mail: sjf{at}post.queensu.ca

There is increasing evidence linking depression and cardiovascular disease. However, the authors could find no literature directly linking depression with atrial fibrillation or atrial flutter. The authors report the case of a patient with uncontrolled atrial arrhythmia who cardioverted to normal sinus rhythm after treatment of major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) with venlafaxine. The authors discuss comorbidity of MDD and atrial fibrillation, and explore evidence of venlafaxine as an antiarrhythmic agent. Further research is needed to establish the clinical role of venlafaxine as a Class 1 antiarrhythmic agent and any association between atrial arrhythmias and MDD and PTSD.







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