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Quetiapine in the Treatment of Behavioral Disturbances in Patients With Huntington’s Disease

Received March 17, 2005; accepted June 25, 2005. From Massachusetts General Hospital, Dept. of Psychiatry, Boston, MA (MA), and Massachusetts General Hospital, Dept. of Neurology, Boston, MA (WJK). Address correspondence and reprint requests to Dr. Alpay, Dept. of Psychiatry, Massachusetts General Hospital, Boston, MA. e-mail: malpay{at}partners.org

The effect of quetiapine (an atypical antipsychotic with minimal extrapyramidal side effects) on motor as well as behavioral symptoms was studied in five consecutive patients with Huntington’s disease in a long-term facility. Improvement of behavioral symptoms (i.e., psychotic symptoms, agitation, irritability, and insomnia) without worsening of motor functioning were noted.

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