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Review of the Literature on Major Mental Disorders in Adult Patients With Mitochondrial Diseases

Received September 21, 2004; revised December 13, 2004, January 19, 2005; accepted March 7, 2005. From The Cleveland Clinic Foundation, Cleveland OH. Send correspondence and reprint requests to Dr. Franco, P57, 9500 Euclid Ave., Cleveland, OH 44195. e-mail: FrancoK{at}ccf.org

Mitochondria are intracellular organelles crucial to the production cellular energy. Mitochondrial disease results from a malfunction in this biochemical cascade. These disorders can affect any organ system, producing diverse signs and symptoms, including psychiatric ones. Several authors argue that mitochondrial dysfunction is related to the pathophysiology of bipolar disorder and schizophrenia. Also, the authors retrieved 19 case reports that describe patients with mitochondrial diseases and psychiatric disorders. Most of these patients have psychiatric presentations that preceded the diagnosis of mitochondrial disease. The most common physical findings are fatigue, muscle weakness with or without atrophy, and hearing loss.

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