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Depression Following Acute Myocardial Infarction: A Prospective Relationship With Ongoing Health and Function

Received Oct. 23, 2003; revision received Nov. 13, 2004; accepted Dec. 16, 2004. From the Department of Psychiatry & Behavioral Sciences, Department of Physical Medicine & Rehabilitation, and Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine; and the Department of Economics, Brooklyn College of the City University of New York, Brooklyn, N.Y. Address correspondence and reprint requests to Dr. Fauerbach, c/o Baltimore Regional Burn Center, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave. Baltimore, MD 21224; JFAUERBA{at}JHMI.edu (e-mail).

The relationship between baseline depression and health-related quality of life were examined in a cohort of patients after hospitalization due to acute myocardial infarction (N=196). Patients were assessed for presence of mood disturbance, anxiety, and quality of life at the time of hospitalization and again 4 months later. Baseline assessment was used to assign subjects to a depressed or a nondepressed group. Adjusting for preinfarction quality of life, in-hospital anxiety, and demographic variables, depression was prospectively and independently related to reduced global health at 4 months as well as reduced overall mental health—including vitality, psychological health, and social function—and increased role interference from psychological problems.

Key Words: myocardial infarction • depression • quality-of-life • comorbidity

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