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Acute Akathisia Associated With Quetiapine Use

Received Aug. 6, 2004; accepted Oct. 26, 2004. From the Department of Psychiatry and Behavioral Medicine and the Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Fla.; James A. Haley Veterans’ Hospital, Tampa, Fla.; and the Department of Psychiatry, University of Florida College of Medicine, Gainesville, Fla. Address correspondence and reprint requests to Dr. Catalano, University of South Florida Psychiatry Center, 3515 East Fletcher Ave., Tampa, FL 33613; gcatalan{at}hsc.usf.edu (e-mail).

Because of their better side-effect profile, atypical antipsychotic agents have replaced conventional antipsychotic agents as the first-line treatment for schizophrenia. Although atypical agents are less likely to be associated with extrapyramidal symptoms, such symptoms sometimes do occur in patients treated with atypical agents. The authors report the cases of two patients who developed akathisia after treatment with quetiapine for insomnia, consider previously reported cases of akathisia induced by atypical antipsychotic agents, discuss other medications that can induce similar symptoms, discuss treatments for akathisia, and examine issues in the use of quetiapine as a soporific agent.

Key Words: Quetiapine • Akathisia • Movement Disorders • Atypical Antipsychotic Agents • Extrapyramidal Symptoms

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