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Antihypertensive Medication Adherence and Blood Pressure Control in Patients With Psychotic Disorders Compared to Persons Without Psychiatric Illness

Received Dec. 9, 2003; revision received April 13, 2004; accepted May 12, 2004. From the Department of Psychiatry, University of California, San Diego, San Diego; the Pharmacy Service and the Psychiatry Service, VA San Diego Healthcare System; and the Wingate University School of Pharmacy, Wingate, N.C. Address correspondence and reprint requests to Dr. Jeste, Geriatric Psychiatry Advanced Center for Interventions and Services Research, VA San Diego Healthcare System, 116A-1, 3350 La Jolla Village Dr., San Diego, CA 92161; djeste{at}ucsd.edu (e-mail).

The authors compared antihypertensive medication adherence and blood pressure control among middle-aged and older outpatients with schizophrenia and related those with psychotic disorders versus persons without any psychiatric illness. A total of 178 subjects were included in the investigation (89 patients with a psychotic disorder and 89 randomly selected, age-matched comparison subjects). Although the two groups had similar antihypertensive medication adherence, the patients with a psychotic disorder were significantly less likely to have had controlled blood pressure during the 1-year study period. The results highlight the need for clinicians to monitor closely the management of medical comorbidity in patients with schizophrenia and related disorders.

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