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Citalopram Treatment of Major Depressive Disorder in Hispanic HIV and AIDS Patients: A Prospective Study

Presented in part at the poster session of the 48th annual meeting of the Academy of Psychosomatic Medicine, San Antonio, Tex., Nov. 15–18, 2001. Received Nov. 29, 2002; revision received July 11, 2003; accepted July 28, 2003. From the Department of Psychiatry and Behavioral Sciences, Division of Consultation Psychiatry, University of Miami School of Medicine. Address reprint requests to Dr. Currier, Division of Consultation Psychiatry, Department of Psychiatry (D-79), University of Miami/Jackson Memorial Medical Center, 1400 N.W. 10th Ave., Suite 304A, Miami, FL 33136; bcurrier{at}med.miami.edu (e-mail).

Fourteen Hispanic and six non-Hispanic outpatients with HIV-spectrum illness and major depressive disorder were enrolled in a 6-week, open-label, flexible-dose study of citalopram (dose range=10–40 mg/day). The depressive symptoms of 50% of the 14 patients who completed the study responded to citalopram (mean dose=34 mg/day). The treatment response rate, effective citalopram dose, total number of reported adverse events, and attrition rate did not differ between the ethnic groups. Two patients discontinued because of adverse events (rash, nausea), and four patients discontinued because of noncompliance with the protocol. The findings suggest that citalopram is an effective and well-tolerated antidepressant for Hispanic and non-Hispanic HIV-infected patients.

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