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Effects of Duloxetine on Painful Physical Symptoms Associated With Depression

Presented in part at the 23rd Collegium Internationale Neuro-Psychopharmacologicum Congress, Montreal, June 23–27, 2002. Received July 16, 2002; revision received March 27, 2003; accepted April 15, 2003. From the Department of Psychiatry and the Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis; PRN Consulting, Indianapolis; the Joint Antidepressant Team—Cymbalta, Lilly Research Laboratories, Indianapolis; the Department of Psychiatry, Harvard Medical School; the Psychiatric Epidemiology Laboratory, McLean Hospital, Belmont, Mass.; and the Department of Neuroscience, Wyeth Pharmaceuticals, Radnor, Pa. Address reprint requests to Dr. Goldstein, PRN Consulting, 1212 Kirkham Lane, Indianapolis, IN 46260; DJGoldstein{at}consultPRNC.com (e-mail).

Painful physical symptoms are common features of major depressive disorder and may be the presenting complaints in primary care settings. The effect of the dual serotonin (5-HT) and norepinephrine reuptake inhibitor duloxetine on emotional and painful physical symptoms in outpatients with major depressive disorder was evaluated in three randomized, double-blind, placebo-controlled trials. The trials' primary objective was to evaluate the effect of duloxetine on mood, and subjects were not enrolled on the basis of presence, type, or severity of pain. However, the pain-relieving effects of duloxetine were evaluated by a priori defined analyses of results from a visual analogue scale and the Somatic Symptom Inventory. Compared with placebo, duloxetine was associated with significant reduction in pain severity. The authors concluded that duloxetine reduces the painful physical symptoms of depression.

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