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An Open Trial of Fluvoxamine for Hypochondriasis

Received Dec. 14, 2001; revision received Sept. 27, 2002; accepted Oct. 18, 2002. From the New York State Psychiatric Institute and the Department of Psychiatry, College of Physicians and Surgeons, Columbia University; and the Division of Family Medicine, St. Joseph Medical Center, Stamford, Conn. Address reprint requests to Dr. Fallon, New York State Psychiatric Institute, 1051 Riverside Dr., Unit 69, New York, NY 10032.

The authors conducted a 12-week, open-label trial of fluvoxamine among 18 patients with DSM-IV hypochondriasis. Response was defined as a physician-rated CGI improvement rating of at least "much improved." Four patients discontinued during the 2-week placebo run-in phase. Among 14 patients given fluvoxamine, the response rate was 72.7% (N=8 of 11) for those completing at least 6 weeks of the trial (minimum-treatment analysis) and 57.1% (N=8 of 14) for the intent-to-treat analysis; these are comparable to rates reported previously for fluoxetine. Significant improvement was also noted on each of the self-report and physician-administered hypochondriasis measures. Fluvoxamine was also well tolerated. A controlled trial is needed.

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