Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Hammerness, P. Articles by Ernst, E. Search for Related Content PubMed Citation Articles by Hammerness, P. Articles by Ernst, E. Other Somatic Therapy

St. John's Wort: A Systematic Review of Adverse Effects and Drug Interactions for the Consultation Psychiatrist

Received May 30, 2002; revision received July 3, 2002; accepted Dec. 13, 2002. From Harvard Medical School, Boston; Massachusetts General Hospital, Boston; Northeastern University, Chicago; the Natural Standard Research Collaboration, the University of Rhode Island, Kingston, R.I.; the University of California, San Francisco; Mt. Sinai School of Medicine, New York; the University of Toronto, Toronto, Ont. Canada; the University of Exeter, Exeter, U.K.; the University of Plymouth, Plymouth, U.K.; Case Western Reserve University School of Medicine, Cleveland; and Harvard School of Public Health, Boston. Address reprint requests to Dr. Ulbricht, Natural Standard Research Collaboration, P.O. Box 390709, Cambridge, MA 02139-0008; kate{at}naturalstandard.com (e-mail).

St. John's wort is an herb commonly used in Europe for decades and more recently the topic of scientific investigation in this country. St. John's wort has been found more effective than placebo and equally as effective as tricyclic antidepressants in the short-term management of mild-to-moderate depression. Comparisons to selective serotonin reuptake inhibitors have provided equivocal data. While it is generally well tolerated in clinical use, there is accumulating evidence of significant interactions with drugs. This evidence-based presentation of the literature includes a brief description of pharmacodynamics and clinical applications, followed by a systematic review of adverse effects, toxicity, and drug interactions.

This article has been cited by other articles:

				C. Carpenter, N. Crigger, R. Kugler, and A. Loya Hypericum and Nurses: A Comprehensive Literature Review on the Efficacy of St. John's Wort in the Treatment of Depression J Holist Nurs, September 1, 2008; 26(3): 200 - 207. [Abstract] [PDF]

				C. Frank Recognition and treatment of serotonin syndrome Can Fam Physician, July 1, 2008; 54(7): 988 - 992. [Full Text] [PDF]

				F. J. Hlubocky, M. J. Ratain, M. Wen, and C. K. Daugherty Complementary and Alternative Medicine Among Advanced Cancer Patients Enrolled on Phase I Trials: A Study of Prognosis, Quality of Life, and Preferences for Decision Making J. Clin. Oncol., February 10, 2007; 25(5): 548 - 554. [Abstract] [Full Text] [PDF]

				T. L. Charrois, C. Sadler, and S. Vohra Complementary, Holistic, and Integrative Medicine: St. John's Wort Pediatr. Rev., February 1, 2007; 28(2): 69 - 72. [Full Text] [PDF]

				K. LINDE, M. BERNER, M. EGGER, and C. MULROW St John's wort for depression: Meta-analysis of randomised controlled trials The British Journal of Psychiatry, February 1, 2005; 186(2): 99 - 107. [Abstract] [Full Text] [PDF]

				E. Mills, V. M Montori, P. Wu, K. Gallicano, M. Clarke, and G. Guyatt Interaction of St John's wort with conventional drugs: systematic review of clinical trials BMJ, July 3, 2004; 329(7456): 27 - 30. [Abstract] [Full Text] [PDF]

				A. Sparreboom, M. C. Cox, M. R. Acharya, and W. D. Figg Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents J. Clin. Oncol., June 15, 2004; 22(12): 2489 - 2503. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2003 Academy of Psychosomatic Medicine. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us