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Symptoms of Pain and Depression in Related Marrow Donors: Changes After Transplant

Received Dec. 3, 2001; revision received May 24, 2002; accepted May 30, 2002. From the Department of Psychiatry, Brigham and Women's Hospital; the Departments of Psychiatry and Medicine, Harvard Medical School, Boston; and the Dana-Farber Cancer Institute, Boston. Address reprint requests to Dr. Chang, Department of Psychiatry, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115; Gchang{at}partners.org (e-mail).

Related or unrelated histocompatible marrow donors make it possible to offer hematopoietic stem cell transplants, the second most frequent solid organ transplant performed in the United States. About 20%–30% of donors are related to the recipient. Despite their importance, relatively little is known about related donors. The purpose of this prospective study is to describe changes in pain and depressive symptoms in 23 related marrow donors before and after marrow donation. Approximately 6 months after marrow donation, related marrow donors whose recipients died had significantly higher Beck Depression Inventory scores than did donors whose related recipients were living.

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