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Immunosuppressants

Dr. Armstrong is the Co-Medical Director, Center for Geriatric Psychiatry, Tuality Forest Grove Hospital, Forest Grove, Ore., and Associate Professor of Psychiatry, Oregon Health Sciences University, Portland, Ore. Dr. Cozza is a psychiatrist for the Infectious Disease Service, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C., and Assistant Professor of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Md. Ms. Pimentel is a 4th-year medical student at the Uniformed Services University of the Health Sciences, Bethesda, Md. Address correspondence and reprint requests to Dr. Armstrong, Tuality Forest Grove Hospital, 1809 Maple St., Forest Grove, OR 97116; scott.armstrong{at}tuality.org (e-mail).

ABSTRACT

This edition of the Med-Psych Drug-Drug Interactions Update begins a change in format. Starting with this column, each column will feature one drug-drug interaction (DDI) topic that will be explored in depth. This edition features DDIs associated with the commonly used immunosuppressants. These drugs are frequently encountered by consultation-liaison psychiatrists in tertiary care settings. Generally, most of these drugs have narrow safety and therapeutic windows; therefore, other drugs that change their serum levels can have deleterious effects. In this review, the DDI profiles of cyclosporine, tacrolimus, sirolimus, and the corticosteroids are explored.

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				M. Fireman, A. F. DiMartini, S. C. Armstrong, and K. L. Cozza Immunosuppressants Psychosomatics, August 1, 2004; 45(4): 354 - 360. [Abstract] [Full Text] [PDF]

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