Psychosomatics 42:247-251, June 2001
© 2001 The Academy of Psychosomatic Medicine
Changes in Lymphocyte Subsets in Depressed HIV-Infected Patients Without Antiretroviral Therapy
Alessandra Alciati, M.D.,
Angelita Ferri, M.D.,
Simona Rozzi, M.D.,
Antonella D'Arminio Monforte, M.D.,
Fabrizia Colmegna, M.D.,
Isabel Valli, and
Carmen Mellado, M.D.
Received May 4, 2000; revised November 27, 2000; accepted November 29, 2000. From the Departments of Psychiatry and Infectious Diseases, L. Sacco Hospital, Milan. Address reprint requests to Dr. Alciati, Ospedale L.Sacco, Department of Psychiatry, Via G.B. Grassi, 74 20157 Milano, Italy.
The authors studied the effects of major depression on lymphocyte subsets by comparing depressed and matched control subjects in a population of HIV-seropositive outpatients not treated with antiretroviral therapy. Twelve patients with major depression, as determined by the Structured Clinical Interview for DSM-III-R, were assessed in comparison with 15 matched nondepressed control subjects. Flow cytometric analysis of peripheral blood lymphocyte subsets together with immunological parameters were performed. In HIV-infected patients, major depression was significantly (P=0.001) associated with a reduction in natural killer cell absolute count and percentage. This report suggests that depression may alter the natural killer cell population that provides a cytotoxic defense against HIV infection.
Key Words: HIV/AIDS • Depression • Antiretroviral Therapy
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