Psychosomatics 42:48-54, February 2001
© 2001 The Academy of Psychosomatic Medicine
Cognitive Improvement With Treatment of Depression Following Mild Traumatic Brain Injury
Jesse R. Fann, M.D., M.P.H.,
Jay M. Uomoto, Ph.D., and
Wayne J. Katon, M.D.
Received March 21, 2000; revised July 11, 2000; accepted September 14, 2000. From Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington; Department of Graduate Psychology, Seattle Pacific University, Seattle, Washington.. Address correspondence and reprint requests to Dr. Fann, M.D., M.P.H., Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195; e-mail: fann{at}u.washington.edu
The authors examined the effect of antidepressant treatment on cognitive performances in people with mild traumatic brain injury. An 8-week nonrandomized, single-blind, placebo run-in trial of sertraline was completed and neuropsychological testing measures were compared before and after the treatment trial. Results showed improvements in psychomotor speed, recent verbal memory, recent visual memory, and general cognitive efficiency. Improvements were also seen in self-perception of cognitive symptomatology. It appears that successful depression treatment resulted in significant alleviation of cognitive impairments, which may not have been accounted for by natural recovery alone.
Key Words: Depression • Cognition • Brain Injury
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