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Hematologic Side Effects of Psychotropics

Received October 9, 1998; revised January 4, 1999; accepted February 17, 1999. From the Department of Psychiatry and Human Behavior, Jefferson Medical College, Philadelphia, Pennsylvania. Address correspondence and reprint requests to Dr. Kunkel, Jefferson Medical College, 1020 Sansom Street, Thompson Bldg., Suite 1652, Philadelphia, PA 19107–5004.

Psychiatrists are often unaware of the potential hematologic complications of the psychotropics they prescribe. Although this review is not a hematologic text reference, relevant hematologic syndromes are described so that the consultation-liaison psychiatrist will be familiar with the usual signs, symptoms, and treatments of these syndromes. This article reviews the hematologic side effects of the commonly prescribed psychotropics, including antipsychotics, antidepressants, benzodiazepines, lithium, mood stabilizers (including some of the anticonvulsants), and the acetylcholinesterase inhibitors. Clinical signs and symptoms that should alert the physician to obtain a complete blood count are described.

Key Words: Side Effects, Hematologic • Psychotropics • Pharmacology

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