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Psychoneuroendocrine Aspects of Temporolimbic Epilepsy

Part III: Case Reports

Received April 2, 1998; revised August 28, 1998; accepted September 10, 1998. From Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School. Address reprint requests to Dr. Herzog, Beth Israel Hospital, 330 Brookline Ave., Boston, MA 02215.

Many reproductive steroids have neuroactive effects that can modulate neuronal excitability and influence emotions. Emotional disorders may result when 1) abnormal endocrine states interact with normal brain, 2) normal endocrine states interact with abnormal brain, and 3) abnormal endocrine states interact with abnormal brain. An understanding of these pathogenetic relationships and the potential therapeutic role of reproductive hormones should lead to a more effective and comprehensive management of women and men with anxiety and mood disorders.

Key Words: Neuropsychiatric Disorders • Epilepsy

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