Psychosomatics 39:422-430, October 1998
© 1998 The Academy of Psychiatric Medicine
Olanzapine in the Treatment of Delirium
Anil Sipahimalani, M.D., and
Prakash S. Masand, M.D.
Received October 3, 1997; revised January 29, 1998; accepted February 11, 1997. From the Department of Psychiatry, State University of New York (SUNY) Health Science Center at Syracuse. Address reprint requests to Dr. Masand, Department of Psychiatry, SUNY Health Science Center at Syracuse, 750 East Adams Street, Syracuse, NY 13210.
Delirium is an organic psychiatric syndrome characterized by fluctuating consciousness and impaired cognitive functioning. Eleven delirious patients were treated with olanzapine (dosage mean ± standard deviation [SD]: 8.2 ± 3.4 mg qhs), and 11 delirious control patients were treated with haloperidol (dosage mean ± SD: 5.1 ± 3.5 mg qhs). Peak response time was similar in both groups. Five of the 11 olanzapine patients showed significant improvement (>50% score reduction) on the Delirium Rating Scale (DRS) and no patients had side effects, whereas 6 of the 11 control subjects showed improvement on the DRS and 5 had extrapyramidal symptoms or excessive sedation. Olanzapine may be a useful alternative to haloperidol in the treatment of delirium in hospitalized patients.
Key Words: Olanzapine • Delirium • cognition
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