Psychosomatics 39:14-17, February 1998
© 1998 The Academy of Psychosomatic Medine
An Open Clinical Trial of Venlafaxine Treatment of Fibromyalgia
Megan M. Dwight, M.D.,
Lesley M. Arnold, M.D.,
Hadley O'Brien, M.S.H.P.A.,
Ray Metzger, B.S.,
Emily Morris-Park, B.A., and
Paul E. Keck, Jr., M.D.
Received September 17, 1996; revised December 4, 1996; accepted February 6, 1997. From the Division of Psychosomatic Research, Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati, Ohio. Address reprint requests to Dr. Arnold, P.O. Box 670559, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Of 15 patients with fibromyalgia who were first evaluated for the presence of Axis I psychiatric diagnoses by use of the Structured Clinical Interview for DSM-IV, 11 completed an open 8-week trial with the novel antidepressant venlafaxine. Six (55%) of 11 completers experienced a  50% reduction of fibromyalgia symptoms. The presence of lifetime psychiatric disorders, particularly depressive and anxiety disorders, predicted a positive response to venlafaxine. These findings suggest that it is important to assess for comorbid psychiatric disorders in patients with fibromyalgia and that venlafaxine may be helpful to some of these patients.
Key Words: Venlafaxine • Fibromyalgia • Antidepressant
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